Analysis of Mitragynine and Other Alkaloids in Mitragyna speciosa Plants Using Supercritical Fluid Chromatography
نویسندگان
چکیده
The FDA has called for the detention of all imports of dietary supplements and bulk dietary ingredients that are or contain Mitragyna speciosa or the natural product kratom derived from this plant, due to the toxicity of kratom in multiple organ systems. The toxicity and psychoactive properties of this plant necessitate improved analytical techniques for the separation of the indole and oxindole compounds that are its major active components. A supercritical fluid chromatography (SFC) method using a diode array detector provided complete resolution of all eight compounds analyzed in this study, including three sets of diastereoisomers, in 7 minutes.
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